{"id":130,"date":"2025-02-02T06:51:37","date_gmt":"2025-02-02T06:51:37","guid":{"rendered":"https:\/\/golanibiophysics.haifa.ac.il\/?p=130"},"modified":"2025-02-02T09:53:17","modified_gmt":"2025-02-02T09:53:17","slug":"theory-of-membrane-fusion-and-fission","status":"publish","type":"post","link":"https:\/\/golanibiophysics.haifa.ac.il\/?p=130","title":{"rendered":"Theory of Membrane Fusion and Fission"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"130\" class=\"elementor elementor-130\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1ce3b66 e-flex e-con-boxed e-con e-parent\" data-id=\"1ce3b66\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-874ed77 elementor-widget elementor-widget-heading\" data-id=\"874ed77\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Theory of Membrane Fusion and Fission<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7ace473 e-con-full e-flex e-con e-child\" data-id=\"7ace473\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-b5eaadc e-con-full e-flex e-con e-child\" data-id=\"b5eaadc\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fe92f66 elementor-widget elementor-widget-text-editor\" data-id=\"fe92f66\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Membrane topological changes are essential for numerous biological processes and are fundamental to life. Membrane fusion occurs during fertilization, muscle cell formation, and intercellular and extracellular trafficking. Membrane fission plays a key role in processes such as exocytosis, mitochondrial division, cytokinesis, reshaping of the endoplasmic reticulum and Golgi apparatus, and the release. Despite the diversity of these processes, they share a common pathway involving a series of lipid rearrangement steps. The energy associated with these steps determines the energy barriers to membrane fusion and fission, and the rates at which these processes occur.<\/p><p>Fusion (viral entry) and fission (viral release) are critical steps in the enveloped virus life cycle. As a result, both viruses and host cells have evolved opposing mechanisms to control the magnitude of these energy barriers to suit their needs. Viruses have developed strategies to lower the energy barriers, facilitating their entry into cells via the plasma and endosomal membranes. In contrast, cells have evolved mechanisms to increase these energy barriers, strengthening their defenses against viral invasion. Our interest is to use physical modeling and computer simulations to better understand this tug-of-war between host and pathogen.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f7b27d7 e-con-full e-flex e-con e-child\" data-id=\"f7b27d7\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d53155b elementor-widget elementor-widget-ucaddon_logo_carousel\" data-id=\"d53155b\" data-element_type=\"widget\" data-widget_type=\"ucaddon_logo_carousel.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\n<!-- start Logo Carousel -->\n\t\t<link id='font-awesome-css' href='https:\/\/golanibiophysics.haifa.ac.il\/wp-content\/plugins\/unlimited-elements-for-elementor-premium\/assets_libraries\/font-awesome6\/fontawesome-all.min.css' type='text\/css' rel='stylesheet' >\n\t\t<link id='font-awesome-4-shim-css' 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!important;\ntext-align:center;\n}\n\n#uc_logo_carousel_elementor_d53155b .owl-dot {\nborder-radius:50%;\ndisplay:inline-block;\n}\n\n\n#uc_logo_carousel_elementor_d53155b{\n\ttext-align: center;\n  position:relative;\n}\n#uc_logo_carousel_elementor_d53155b .uc_logo_carousel_holder{\n    display:flex;\n    align-items: center;\n    justify-content:center;\n    flex-wrap: wrap;\n    width: 100%;\n}\n#uc_logo_carousel_elementor_d53155b .uc_logo_carousel_holder a\n{height:100%;\n    width: 100%;\n  display:flex;\n  align-items: center;\n    justify-content:center;\n}\n\n#uc_logo_carousel_elementor_d53155b  img{\n    height:100%;\n    width: 100%;\n    object-fit: contain;\n}\n\n\n\n\n<\/style>\n\n<div class=\"uc_logo_carousel\"  style=\"direction:ltr;\">\n   <div class=\"uc_carousel owl-carousel owl-theme uc-items-wrapper  \" id=\"uc_logo_carousel_elementor_d53155b\"   data-new-tab=\"false\">\n   \t\t\n<div class=\"uc_logo_carousel\">\n    \n    <div class=\"uc_logo_carousel_holder ue-item\">\n          <a href=\"#\" >\n          <img fetchpriority=\"high\" decoding=\"async\" src=\"https:\/\/golanibiophysics.haifa.ac.il\/wp-content\/uploads\/2025\/02\/3D-hemifusion.png\"  src=\"https:\/\/golanibiophysics.haifa.ac.il\/wp-content\/uploads\/2025\/02\/3D-hemifusion.png\" alt=\"3D hemifusion\" width=\"437\" height=\"431\" >\n          <\/a>\n    <\/div>\n\t\n      \n<\/div>\n\n<div class=\"uc_logo_carousel\">\n    \n    <div class=\"uc_logo_carousel_holder ue-item\">\n          <a href=\"#\" >\n          <img decoding=\"async\" src=\"https:\/\/golanibiophysics.haifa.ac.il\/wp-content\/uploads\/2025\/02\/Fusion-pathway-scaled.jpg\"  src=\"https:\/\/golanibiophysics.haifa.ac.il\/wp-content\/uploads\/2025\/02\/Fusion-pathway-scaled.jpg\" alt=\"Membrane Fusion and fission02\" width=\"2560\" height=\"1746\" >\n          <\/a>\n    <\/div>\n\t\n      \n<\/div>\n\n<div class=\"uc_logo_carousel\">\n    \n    <div class=\"uc_logo_carousel_holder ue-item\">\n          <a href=\"#\" >\n          <img decoding=\"async\" src=\"https:\/\/golanibiophysics.haifa.ac.il\/wp-content\/uploads\/2025\/02\/membrane-undulations.png\"  src=\"https:\/\/golanibiophysics.haifa.ac.il\/wp-content\/uploads\/2025\/02\/membrane-undulations.png\" alt=\"Membrane Fusion and fission04\" width=\"794\" height=\"526\" >\n          <\/a>\n    <\/div>\n\t\n      \n<\/div>\n\n<div class=\"uc_logo_carousel\">\n    \n    <div class=\"uc_logo_carousel_holder ue-item\">\n          <a href=\"#\" >\n          <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/golanibiophysics.haifa.ac.il\/wp-content\/uploads\/2025\/02\/Hemifusion-diaphragm.png\"  src=\"https:\/\/golanibiophysics.haifa.ac.il\/wp-content\/uploads\/2025\/02\/Hemifusion-diaphragm.png\" alt=\"Membrane Fusion and fission03\" width=\"2523\" height=\"1726\" >\n          <\/a>\n    <\/div>\n\t\n      \n<\/div>\n\n   <\/div>\t\n<\/div>\n<!-- end Logo Carousel -->\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Theory of Membrane Fusion and Fission Membrane topological changes are essential for numerous biological processes and are fundamental to life. Membrane fusion occurs during fertilization, muscle cell formation, and intercellular and extracellular trafficking. Membrane fission plays a key role in processes such as exocytosis, mitochondrial division, cytokinesis, reshaping of the endoplasmic reticulum and Golgi apparatus, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":132,"comment_status":"open","ping_status":"open","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[],"class_list":["post-130","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-interests","entry","has-media"],"_links":{"self":[{"href":"https:\/\/golanibiophysics.haifa.ac.il\/index.php?rest_route=\/wp\/v2\/posts\/130","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/golanibiophysics.haifa.ac.il\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/golanibiophysics.haifa.ac.il\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/golanibiophysics.haifa.ac.il\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/golanibiophysics.haifa.ac.il\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=130"}],"version-history":[{"count":22,"href":"https:\/\/golanibiophysics.haifa.ac.il\/index.php?rest_route=\/wp\/v2\/posts\/130\/revisions"}],"predecessor-version":[{"id":289,"href":"https:\/\/golanibiophysics.haifa.ac.il\/index.php?rest_route=\/wp\/v2\/posts\/130\/revisions\/289"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/golanibiophysics.haifa.ac.il\/index.php?rest_route=\/wp\/v2\/media\/132"}],"wp:attachment":[{"href":"https:\/\/golanibiophysics.haifa.ac.il\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=130"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/golanibiophysics.haifa.ac.il\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=130"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/golanibiophysics.haifa.ac.il\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=130"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}